CCT6A

Protein-coding gene in humans From Wikipedia, the free encyclopedia

T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.[5][6][7]

AliasesCCT6A, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20, chaperonin containing TCP1 subunit 6A
End56,063,989 bp[1]
Quick facts Identifiers, Aliases ...
CCT6A
Identifiers
AliasesCCT6A, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20, chaperonin containing TCP1 subunit 6A
External IDsOMIM: 104613; MGI: 107943; HomoloGene: 1336; GeneCards: CCT6A; OMA:CCT6A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001762
NM_001009186

NM_009838

RefSeq (protein)

NP_001009186
NP_001753

NP_033968

Location (UCSC)Chr 7: 56.05 – 56.06 MbChr 5: 129.86 – 129.88 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[7]

Interactions

CCT6A has been shown to interact with PPP4C.[8][9]

References

Further reading

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