CCT6B

T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.^[5][6][7]

AliasesCCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B

External IDsOMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs

Chr.Chromosome 17 (human)^[1]

End34,981,078 bp^[1]

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CCT6B
Identifiers
Aliases	CCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDs	OMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 34,927,859 bp[1] End 34,981,078 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 82,610,076 bp[2] End 82,655,147 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis testicle gonad olfactory zone of nasal mucosa Achilles tendon gastrocnemius muscle palpebral conjunctiva gastric mucosa Top expressed in spermatid spermatocyte seminiferous tubule blastocyst embryo Ileal epithelium embryo morula morula right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATP binding protein folding chaperone activity unfolded protein binding Cellular component cytoplasm cytosol chaperonin-containing T-complex Biological process toxin transport protein folding chaperone-mediated protein complex assembly spermatogenesis protein transport 'de novo' protein folding chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10693 12467 Ensembl ENSG00000132141 ENSMUSG00000020698 UniProt Q92526 Q61390 RefSeq (mRNA) NM_001193529 NM_001193530 NM_006584 NM_001291242 NM_009839 RefSeq (protein) NP_001180458 NP_001180459 NP_006575 NP_001278171 NP_033969 Location (UCSC) Chr 17: 34.93 – 34.98 Mb Chr 11: 82.61 – 82.66 Mb PubMed search [3] [4]
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This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[7]