CD164

Sialomucin core protein 24 also known as endolyn or CD164 (cluster of differentiation 164) is a protein that in humans is encoded by the CD164 gene.^[5][6] CD164 functions as a cell adhesion molecule.

AliasesCD164, MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v

External IDsOMIM: 603356; MGI: 1859568; HomoloGene: 38129; GeneCards: CD164; OMA:CD164 - orthologs

Chr.Chromosome 6 (human)^[1]

End109,382,467 bp^[1]

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CD164
Identifiers
Aliases	CD164, MGC-24, MUC-24, endolyn, DFNA66, CD164 molecule, MGC-24v
External IDs	OMIM: 603356; MGI: 1859568; HomoloGene: 38129; GeneCards: CD164; OMA:CD164 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 109,366,514 bp[1] End 109,382,467 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.46 cM Start 41,395,410 bp[2] End 41,407,044 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon bronchial epithelial cell kidney tubule secondary oocyte skin of hip lactiferous duct rectum epithelium of nasopharynx glomerulus skin of thigh Top expressed in parotid gland submandibular gland epithelium of lens Epithelium of choroid plexus iris retinal pigment epithelium lacrimal gland vestibular membrane of cochlear duct cornea islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane extracellular region lysosomal membrane endosome plasma membrane lysosome integral component of plasma membrane endosome membrane membrane cytoplasmic vesicle Biological process multicellular organism development negative regulation of cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion muscle organ development immune response signal transduction negative regulation of cell population proliferation hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8763 53599 Ensembl ENSG00000135535 ENSMUSG00000019818 UniProt Q04900 Q9R0L9 RefSeq (mRNA) NM_006016 NM_001142401 NM_001142402 NM_001142403 NM_001142404 NM_001346500 NM_016898 RefSeq (protein) NP_001135873 NP_001135874 NP_001135875 NP_001135876 NP_001333429 NP_006007 NP_058594 Location (UCSC) Chr 6: 109.37 – 109.38 Mb Chr 10: 41.4 – 41.41 Mb PubMed search [3] [4]
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Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play two key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor.^[5]

A genome wide CRISPR/Cas9 screen in human A549 cells identified CD164 as an internal entry receptor for the arenavirus Lymphocytic Choriomeningitis Virus (LCMV) ^[7].