CD177

CD177 antigen is a protein that in humans is encoded by the CD177 gene.^[5][6][7]

AliasesCD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule

External IDsOMIM: 162860; MGI: 1916141; HomoloGene: 49628; GeneCards: CD177; OMA:CD177 - orthologs

Chr.Chromosome 19 (human)^[1]

End43,363,172 bp^[1]

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CD177
Identifiers
Aliases	CD177, HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 molecule
External IDs	OMIM: 162860; MGI: 1916141; HomoloGene: 49628; GeneCards: CD177; OMA:CD177 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.31 Start 43,353,686 bp[1] End 43,363,172 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 24,443,408 bp[2] End 24,459,736 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum mucosa of colon mucosa of sigmoid colon mucosa of transverse colon bone marrow bone marrow cell spleen trabecular bone prostate blood Top expressed in granulocyte tibiofemoral joint primary oocyte secondary oocyte zygote large intestine colon left colon bone marrow trachea More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protease binding integrin binding calcium-dependent protein binding Cellular component anchored component of membrane extracellular exosome membrane specific granule membrane plasma membrane secretory granule membrane plasma membrane raft tertiary granule membrane extracellular region lamellipodium cell projection membrane raft Biological process blood coagulation leukocyte migration neutrophil degranulation cell adhesion leukocyte cell-cell adhesion regulation of endocytosis positive regulation of superoxide anion generation protein localization to cell surface positive regulation of neutrophil degranulation cell-cell junction maintenance neutrophil extravasation cell-cell adhesion via plasma-membrane adhesion molecules neutrophil migration regulation of integrin-mediated signaling pathway immune system process innate immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57126 68891 Ensembl ENSG00000204936 ENSMUSG00000052212 UniProt Q8N6Q3 Q8R2S8 RefSeq (mRNA) NM_020406 NM_026862 RefSeq (protein) NP_065139 NP_081138 Location (UCSC) Chr 19: 43.35 – 43.36 Mb Chr 7: 24.44 – 24.46 Mb PubMed search [3] [4]
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NB1, a glycosyl-phosphatidylinositol (GPI)-linked N-glycosylated cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia (Lalezari et al., 1971). [supplied by OMIM]^[7]