CD248

Endosialin is a protein that in humans is encoded by the CD248 gene.^[5][6][7]

AliasesCD248, CD164L1, TEM1, CD248 molecule

External IDsOMIM: 606064; MGI: 1917695; HomoloGene: 10699; GeneCards: CD248; OMA:CD248 - orthologs

Chr.Chromosome 11 (human)^[1]

End66,317,044 bp^[1]

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CD248
Identifiers
Aliases	CD248, CD164L1, TEM1, CD248 molecule
External IDs	OMIM: 606064; MGI: 1917695; HomoloGene: 10699; GeneCards: CD248; OMA:CD248 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 66,314,494 bp[1] End 66,317,044 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,118,106 bp[2] End 5,120,710 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua stromal cell of endometrium subcutaneous adipose tissue gastric mucosa synovial joint pericardium canal of the cervix left uterine tube ectocervix skin of hip Top expressed in external carotid artery internal carotid artery molar lip occiput occipital bone ankle efferent ductule sciatic nerve dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding extracellular matrix binding carbohydrate binding molecular function extracellular matrix protein binding Cellular component cytoplasm integral component of membrane extracellular exosome membrane extracellular matrix external side of plasma membrane Biological process positive regulation of endothelial cell apoptotic process lymph node development cell migration positive regulation of cell population proliferation anatomical structure regression biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57124 70445 Ensembl ENSG00000174807 ENSMUSG00000056481 UniProt Q9HCU0 Q91V98 RefSeq (mRNA) NM_020404 NM_054042 RefSeq (protein) NP_065137 NP_473383 Location (UCSC) Chr 11: 66.31 – 66.32 Mb Chr 19: 5.12 – 5.12 Mb PubMed search [3] [4]
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Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized.^[8]

The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.^[9]