IGSF8

IGSF8
Identifiers
Aliases	IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	OMIM: 606644; MGI: 2154090; HomoloGene: 14163; GeneCards: IGSF8; OMA:IGSF8 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,098,943 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	172,147,408 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; C1 segment; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; hypothalamus; ; nucleus accumbens;
	Top expressed in
	ventricular zone; ; primary visual cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; perirhinal cortex; ; superior colliculus; ; respiratory epithelium; ; nasal epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular exosome; membrane; integral component of membrane; plasma membrane;
Biological process	skeletal muscle tissue development; nervous system development; cell population proliferation; single fertilization; cell motility;
	Sources:Amigo / QuickGO
Orthologs
	93185
	140559
	ENSG00000162729
	ENSMUSG00000038034
	Q969P0
	Q8R366
	NM_001206665; NM_052868; NM_001320247
	NM_080419
	NP_001193594; NP_001307176; NP_443100
	NP_536344
	Wikidata
View/Edit Human	View/Edit Mouse

Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.^[5]^[6]^[7] IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.^[8] IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor).^[8] IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer,^[8] and has been proposed as a potential therapeutic target in gliomas.^[9] In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.^[8]