CD3G

T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene.

PDBOrtholog search: PDBe RCSB

AliasesCD3G, CD3-GAMMA, IMD17, T3G, CD3g molecule, CD3GAMMA, CD3 gamma subunit of T-cell receptor complex

External IDsOMIM: 186740; MGI: 88333; HomoloGene: 55; GeneCards: CD3G; OMA:CD3G - orthologs

Chr.Chromosome 11 (human)^[1]

Quick facts Available structures, PDB ...

CD3G
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SY6
Identifiers
Aliases	CD3G, CD3-GAMMA, IMD17, T3G, CD3g molecule, CD3GAMMA, CD3 gamma subunit of T-cell receptor complex
External IDs	OMIM: 186740; MGI: 88333; HomoloGene: 55; GeneCards: CD3G; OMA:CD3G - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 118,344,344 bp[1] End 118,355,161 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 24.84 cM Start 44,880,870 bp[2] End 44,891,729 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell lymph node thymus granulocyte blood appendix epithelium of colon superficial temporal artery testicle bone marrow cell Top expressed in thymus mesenteric lymph nodes superior surface of tongue gallbladder blood spleen ankle joint subcutaneous adipose tissue duodenum jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor complex adaptor activity T cell receptor binding transmembrane signaling receptor activity protein heterodimerization activity protein homodimerization activity Cellular component integral component of membrane alpha-beta T cell receptor complex integral component of plasma membrane T cell receptor complex membrane clathrin-coated vesicle membrane plasma membrane external side of plasma membrane Biological process protein transport establishment or maintenance of cell polarity cell surface receptor signaling pathway T cell receptor signaling pathway regulation of lymphocyte apoptotic process T cell activation Fc-gamma receptor signaling pathway involved in phagocytosis regulation of immune response membrane organization protein homooligomerization adaptive immune response immune system process protein-containing complex assembly T cell differentiation positive thymic T cell selection positive regulation of signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 917 12502 Ensembl ENSG00000160654 ENSMUSG00000002033 UniProt P09693 P11942 RefSeq (mRNA) NM_000073 NM_009850 RefSeq (protein) NP_000064 NP_033980 Location (UCSC) Chr 11: 118.34 – 118.36 Mb Chr 9: 44.88 – 44.89 Mb PubMed search [3] [4]
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T cell antigen receptor (TCR) is associated on the T cell surface with a complex of protein called CD3. CD3G (gamma chain) is one of the four peptides (gamma, delta, epsilon and zeta) that form CD3. Defects in CD3G are associated with T cell immunodeficiency.^[5]