CD6

Human protein From Wikipedia, the free encyclopedia

CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[5][6]

Quick facts Available structures, PDB ...
CD6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCD6, TP120, CD6 molecule
External IDsOMIM: 186720; MGI: 103566; HomoloGene: 4893; GeneCards: CD6; OMA:CD6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001254750
NM_001254751
NM_006725

NM_001037801
NM_009852

RefSeq (protein)

NP_001241679
NP_001241680
NP_006716

NP_001032890
NP_033982

Location (UCSC)Chr 11: 60.97 – 61.02 MbChr 19: 10.77 – 10.81 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation.[5]

Clinical significance

Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[7][8]

See also

References

Further reading

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