CD7

Mammalian protein found in humans From Wikipedia, the free encyclopedia

CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[5]

AliasesCD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
End82,317,608 bp[1]
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CD7
Identifiers
AliasesCD7, GP40, LEU-9, TP41, Tp40, CD7 molecule
External IDsOMIM: 186820; MGI: 88344; HomoloGene: 4471; GeneCards: CD7; OMA:CD7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006137

NM_009854

RefSeq (protein)

NP_006128

NP_033984

Location (UCSC)Chr 17: 82.31 – 82.32 MbChr 11: 120.93 – 120.93 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[5]

See also

Interactions

CD7 has been shown to interact with PIK3R1.[6][7]

Clinical significance

CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[8] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[9]

References

Further reading

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