CDC37

Available protein structures:
PDB	IPR013855 PF03234 (ECOD; PDBsum)
AlphaFold	IPR013855; PF03234;

Cdc37 N terminal kinase binding
Cdc37 N terminal kinase binding
Identifiers
Symbol	CDC37_N
Pfam	PF03234
InterPro	IPR013855
SCOP2	1us7 / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR013855 PF03234 (ECOD; PDBsum)
AlphaFold	IPR013855; PF03234;

CDC37
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1US7, 2K5B, 2W0G, 2N5X, 2NCA, 5FWM, 5FWL, 5FWK
Identifiers
Aliases	CDC37, P50cell division cycle 37, cell division cycle 37, HSP90 cochaperone
External IDs	OMIM: 605065; MGI: 109531; HomoloGene: 38268; GeneCards: CDC37; OMA:CDC37 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,420,121 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,061,278 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; apex of heart; ; granulocyte; ; body of uterus; ; left uterine tube; ; upper lobe of left lung; ; left lobe of thyroid gland; ; gastric mucosa; ; right uterine tube; ; canal of the cervix;
	Top expressed in
	maxillary prominence; ; mandibular prominence; ; right ventricle; ; neural layer of retina; ; somite; ; dentate gyrus of hippocampal formation granule cell; ; epiblast; ; abdominal wall; ; efferent ductule; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; Hsp90 protein binding; kinase binding; chaperone binding; protein binding; protein kinase binding; heat shock protein binding; protein kinase regulator activity; protein tyrosine kinase activity; scaffold protein binding;
Cellular component	extracellular exosome; HSP90-CDC37 chaperone complex; cytoplasm; cytosol; chaperone complex;
Biological process	posttranscriptional regulation of gene expression; protein targeting; protein stabilization; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; positive regulation of mitophagy in response to mitochondrial depolarization; regulation of protein kinase activity; protein folding; peptidyl-tyrosine phosphorylation; ERBB2 signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	11140
	12539
	ENSG00000105401
	ENSMUSG00000019471
	Q16543
	Q61081
	NM_007065
	NM_016742; NM_001378796
	NP_008996
	NP_058022; NP_001365725
	Wikidata
View/Edit Human	View/Edit Mouse

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.^[5] This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone^[6] with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.^[7]