CDC42BPA

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.^[5]

AliasesCDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha

External IDsOMIM: 603412; MGI: 2441841; HomoloGene: 55765; GeneCards: CDC42BPA; OMA:CDC42BPA - orthologs

Chr.Chromosome 1 (human)^[1]

End227,318,492 bp^[1]

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CDC42BPA
Identifiers
Aliases	CDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDs	OMIM: 603412; MGI: 2441841; HomoloGene: 55765; GeneCards: CDC42BPA; OMA:CDC42BPA - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 226,989,865 bp[1] End 227,318,492 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 179,788,037 bp[2] End 179,993,168 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in internal globus pallidus pylorus tibia lateral nuclear group of thalamus secondary oocyte external globus pallidus pars reticulata renal medulla Brodmann area 23 corpus callosum Top expressed in zygote superior frontal gyrus primary visual cortex cerebellar cortex dentate gyrus of hippocampal formation granule cell genital tubercle central gray substance of midbrain neural layer of retina medial geniculate nucleus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine kinase activity protein kinase activity protein binding ATP binding magnesium ion binding metal ion binding identical protein binding kinase activity Cellular component cytoplasm actomyosin extracellular exosome cell leading edge cell-cell junction lamellipodium cell projection cytoskeleton Biological process protein phosphorylation actomyosin structure organization intracellular signal transduction cell migration phosphorylation actin cytoskeleton reorganization actin cytoskeleton organization peptidyl-threonine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8476 226751 Ensembl ENSG00000143776 ENSMUSG00000026490 UniProt Q5VT25 Q3UU96 RefSeq (mRNA) NM_003607 NM_014826 NM_001366010 NM_001366011 NM_001366019 NM_001387550 NM_001394014 NM_001033285 NM_001346804 NM_001346805 NM_001359541 NM_001359542 NM_001359543 NM_001359544 NM_001359545 NM_001359546 NM_001359547 NM_001359548 NM_001359549 RefSeq (protein) NP_003598 NP_055641 NP_001352939 NP_001352940 NP_001352948 NP_001028457 NP_001333733 NP_001333734 NP_001346470 NP_001346471 NP_001346472 NP_001346473 NP_001346474 NP_001346475 NP_001346476 NP_001346477 NP_001346478 Location (UCSC) Chr 1: 226.99 – 227.32 Mb Chr 1: 179.79 – 179.99 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.^[5]