CDC42EP4

Cdc42 effector protein 4 is a protein that in humans is encoded by the CDC42EP4 gene.^[5][6][7]

AliasesCDC42EP4, BORG4, CEP4, KAIA1777, CDC42 effector protein 4

External IDsOMIM: 605468; MGI: 1929760; HomoloGene: 8110; GeneCards: CDC42EP4; OMA:CDC42EP4 - orthologs

Chr.Chromosome 17 (human)^[1]

End73,312,005 bp^[1]

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CDC42EP4
Identifiers
Aliases	CDC42EP4, BORG4, CEP4, KAIA1777, CDC42 effector protein 4
External IDs	OMIM: 605468; MGI: 1929760; HomoloGene: 8110; GeneCards: CDC42EP4; OMA:CDC42EP4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 73,283,624 bp[1] End 73,312,005 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 113,617,676 bp[2] End 113,642,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve paraflocculus of cerebellum olfactory bulb left uterine tube ventricular zone middle frontal gyrus olfactory zone of nasal mucosa internal globus pallidus corpus epididymis external globus pallidus Top expressed in vestibular sensory epithelium internal carotid artery external carotid artery vestibular membrane of cochlear duct medullary collecting duct Rostral migratory stream spermatocyte left lung lobe ventricular zone utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity RNA binding Cellular component endomembrane system plasma membrane cytoskeleton microtubule cytoskeleton membrane actin cytoskeleton cytoplasm phagocytic vesicle Biological process positive regulation of actin filament polymerization positive regulation of pseudopodium assembly regulation of cell shape Rho protein signal transduction positive regulation of GTPase activity cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23580 56699 Ensembl ENSG00000179604 ENSMUSG00000041598 UniProt Q9H3Q1 Q9JM96 RefSeq (mRNA) NM_012121 NM_001163346 NM_020006 RefSeq (protein) NP_036253 NP_001156818 NP_064390 Location (UCSC) Chr 17: 73.28 – 73.31 Mb Chr 11: 113.62 – 113.64 Mb PubMed search [3] [4]
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The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control.^[7]