CDC5L
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.[5][6][7]
External IDsOMIM: 602868; MGI: 1918952; HomoloGene: 13291; GeneCards: CDC5L; OMA:CDC5L - orthologs
Function
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.[7]
Interactions
CDC5L has been shown to interact with:
- ASF/SF2,[8]
- BZW1,[8]
- CWC15,[8]
- DNA-PKcs,[8]
- DYNC1H1,[8]
- GCN1L1,[8]
- HSPA8,[8]
- ILF2,[8]
- PLRG1,[8][9][10][11]
- PPM1D,[8]
- PPP1CA,[8]
- PRPF19,[8]
- RBMX[8] and
- RPL12,[8]
- RPL13,[8]
- RPS16,[8]
- RPS25,[8]
- SF3A1,[8]
- SF3B1,[8]
- SF3B2,[8]
- SF3B4,[8]
- SFPQ,[8]
- SRSF2,[8]
- SNRPA1,[8]
- SNRPD3,[8]
- SRRM1,[8]
- Small nuclear ribonucleoprotein D1,[8]
- Small nuclear ribonucleoprotein D2,[8]
- Small nuclear ribonucleoprotein polypeptide A,[8]
- TOP2A,[8] and
- TTF2.[12]