CDCA7

Cell division cycle-associated protein 7 is a protein that in humans is encoded by the CDCA7 gene.^[5][6][7]

AliasesCDCA7, JPO1, ICF3, cell division cycle associated 7

External IDsOMIM: 609937; MGI: 1914203; HomoloGene: 49970; GeneCards: CDCA7; OMA:CDCA7 - orthologs

Chr.Chromosome 2 (human)^[1]

End173,368,997 bp^[1]

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CDCA7
Identifiers
Aliases	CDCA7, JPO1, ICF3, cell division cycle associated 7
External IDs	OMIM: 609937; MGI: 1914203; HomoloGene: 49970; GeneCards: CDCA7; OMA:CDCA7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 173,354,820 bp[1] End 173,368,997 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 72,306,503 bp[2] End 72,317,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum ventricular zone ganglionic eminence thymus rectum mucosa of sigmoid colon gonad duodenum jejunal mucosa pylorus Top expressed in ventricular zone thymus epiblast medial ganglionic eminence tail of embryo hand primitive streak embryo mandibular prominence abdominal wall More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 83879 66953 Ensembl ENSG00000144354 ENSMUSG00000055612 UniProt Q9BWT1 Q9D0M2 RefSeq (mRNA) NM_031942 NM_145810 NM_025866 RefSeq (protein) NP_114148 NP_665809 NP_080142 Location (UCSC) Chr 2: 173.35 – 173.37 Mb Chr 2: 72.31 – 72.32 Mb PubMed search [3] [4]
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This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.^[7]