CDH12

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.^[5][6]

AliasesCDH12, CDHB, cadherin 12

External IDsOMIM: 600562; MGI: 109503; HomoloGene: 37873; GeneCards: CDH12; OMA:CDH12 - orthologs

Chr.Chromosome 5 (human)^[1]

End22,853,622 bp^[1]

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CDH12
Identifiers
Aliases	CDH12, CDHB, cadherin 12
External IDs	OMIM: 600562; MGI: 109503; HomoloGene: 37873; GeneCards: CDH12; OMA:CDH12 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p14.3 Start 21,750,673 bp[1] End 22,853,622 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 A2|15 8.25 cM Start 20,449,351 bp[2] End 21,589,619 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle middle temporal gyrus postcentral gyrus Brodmann area 23 right uterine tube primary visual cortex frontal pole Brodmann area 10 superior frontal gyrus entorhinal cortex Top expressed in internal pyramidal layer of neocortex external pyramidal layer of neocortex granular layer of dentate gyrus external granular layer dentate gyrus of hippocampal formation granule cell thalamus primary visual cortex epithalamus CA3 field dorsal cochlear nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane cell surface catenin complex Biological process cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1010 215654 Ensembl ENSG00000154162 ENSMUSG00000040452 UniProt P55289 Q5RJH3 RefSeq (mRNA) NM_004061 NM_001317227 NM_001317228 NM_001008420 RefSeq (protein) NP_001304156 NP_001304157 NP_004052 NP_001351033 NP_001351034 NP_001351035 NP_001351036 NP_001351037 NP_001351038 NP_001008420 Location (UCSC) Chr 5: 21.75 – 22.85 Mb Chr 15: 20.45 – 21.59 Mb PubMed search [3] [4]
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This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.^[6]