CDH15

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[5][6]

AliasesCDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
End89,195,492 bp[1]
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CDH15
Identifiers
AliasesCDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDsOMIM: 114019; MGI: 106672; HomoloGene: 3622; GeneCards: CDH15; OMA:CDH15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004933

NM_007662

RefSeq (protein)

NP_004924

NP_031688

Location (UCSC)Chr 16: 89.17 – 89.2 MbChr 8: 123.57 – 123.59 Mb
PubMed search[3][4]
Wikidata
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Function

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[6]

Interactions

CDH15 has been shown to interact with ARVCF.[7]

References

Further reading

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