CDH16

Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.^[5][6][7]

AliasesCDH16, cadherin 16

External IDsOMIM: 603118; MGI: 106671; HomoloGene: 2997; GeneCards: CDH16; OMA:CDH16 - orthologs

Chr.Chromosome 16 (human)^[1]

End66,918,917 bp^[1]

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CDH16
Identifiers
Aliases	CDH16, cadherin 16
External IDs	OMIM: 603118; MGI: 106671; HomoloGene: 2997; GeneCards: CDH16; OMA:CDH16 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 66,908,122 bp[1] End 66,918,917 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.04 cM Start 105,328,543 bp[2] End 105,351,028 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla kidney tubule left lobe of thyroid gland right lobe of thyroid gland glomerulus metanephric glomerulus human kidney muscle of thigh caput epididymis gonad Top expressed in human kidney right kidney medullary collecting duct proximal tubule efferent ductule vas deferens renal corpuscle left lung lobe renal pelvis trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane integral component of plasma membrane basolateral plasma membrane Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1014 12556 Ensembl ENSG00000166589 ENSMUSG00000031881 UniProt O75309 O88338 RefSeq (mRNA) NM_001204744 NM_001204745 NM_001204746 NM_004062 NM_001252627 NM_001252628 NM_007663 RefSeq (protein) NP_001191673 NP_001191674 NP_001191675 NP_004053 NP_001239556 NP_001239557 NP_031689 Location (UCSC) Chr 16: 66.91 – 66.92 Mb Chr 8: 105.33 – 105.35 Mb PubMed search [3] [4]
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This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.^[7]