CEACAM5
Mammalian protein found in Homo sapiens
From Wikipedia, the free encyclopedia
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.[3]
Functions
In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.[4][5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.[6] Also, it plays a significant role in the inhibition of differentiation [7] and apoptosis [8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).[10][11]