CENPC1

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.^[5][6]

AliasesCENPC, CENP-C, CENPC1, MIF2, hcp-4, centromere protein C

External IDsOMIM: 117141; MGI: 99700; GeneCards: CENPC

Chr.Chromosome 4 (human)^[1]

End67,545,503 bp^[1]

Quick facts CENPC, Identifiers ...

CENPC
Identifiers
Aliases	CENPC, CENP-C, CENPC1, MIF2, hcp-4, centromere protein C
External IDs	OMIM: 117141; MGI: 99700; GeneCards: CENPC
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.2 Start 67,468,762 bp[1] End 67,545,503 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E1 Start 86,159,883 bp[2] End 86,213,442 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon sural nerve corpus callosum bone marrow cell testicle tonsil body of pancreas gonad ventricular zone lymph node Top expressed in spermatocyte tail of embryo genital tubercle ventricular zone Gonadal ridge otic placode superior cervical ganglion abdominal wall otic vesicle saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding centromeric DNA binding protein binding identical protein binding Cellular component pericentric heterochromatin chromosome chromosome, centromeric region kinetochore nucleus nucleoplasm cytosol nuclear body midbody cleavage furrow intercellular bridge Flemming body Biological process chromosome segregation cell division kinetochore assembly cell cycle CENP-A containing chromatin assembly attachment of mitotic spindle microtubules to kinetochore monopolar spindle attachment to meiosis I kinetochore mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1060 12617 Ensembl ENSG00000145241 ENSMUSG00000029253 UniProt Q03188 P49452 RefSeq (mRNA) NM_001812 NM_001362481 NM_007683 NM_001345902 NM_001345903 NM_001345904 RefSeq (protein) NP_001803 NP_001349410 NP_001332831 NP_001332832 NP_001332833 NP_031709 Location (UCSC) Chr 4: 67.47 – 67.55 Mb Chr 5: 86.16 – 86.21 Mb PubMed search [3] [4]
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Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.^[6]