CENTD1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ARAP2 gene.[5]

PDBOrtholog search: PDBe RCSB
AliasesARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Quick facts ARAP2, Available structures ...
ARAP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARAP2, CENTD1, PARX, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
External IDsOMIM: 606645; MGI: 2684416; HomoloGene: 9064; GeneCards: ARAP2; OMA:ARAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015230
NM_139182

NM_178407

RefSeq (protein)

NP_056045

n/a

Location (UCSC)Chr 4: 35.95 – 36.24 MbChr 5: 62.76 – 62.92 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. This protein lacks the predicted catalytic arginine in the RHO-GAP domain and is therefore unlikely to have RHO-GAP activity. While the encoded protein does contain a sterile alpha motif (SAM) commonly found in some signaling molecules, the function of the protein has not been determined. Two transcript variants encoding different isoforms have been found for this gene.[5]

References

Further reading

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