CEP135

CEP135
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FCN
Identifiers
Aliases	CEP135, CEP4, KIAA0635, MCPH8, centrosomal protein 135
External IDs	OMIM: 611423; MGI: 2681869; HomoloGene: 45709; GeneCards: CEP135; OMA:CEP135 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	56,033,361 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	76,794,313 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; buccal mucosa cell; ; sperm; ; ventricular zone; ; testicle; ; gonad; ; bone marrow; ; monocyte; ; Achilles tendon; ; secondary oocyte;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; secondary oocyte; ; spermatid; ; spermatocyte; ; granulocyte; ; ventricular zone; ; primary oocyte; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; protein binding;
Cellular component	cytoplasm; centriole; cytosol; centrosome; cytoskeleton;
Biological process	centriole replication; centriole-centriole cohesion; G2/M transition of mitotic cell cycle; positive regulation of non-motile cilium assembly; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; positive regulation of establishment of protein localization;
	Sources:Amigo / QuickGO
Orthologs
	9662
	381644
	ENSG00000174799
	ENSMUSG00000036403
	Q66GS9
	Q6P5D4
	NM_014645; NM_025009
	NM_199032
	NP_079285
	NP_950197
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene.^[5]^[6]^[7] It is part of the centrosome throughout the cell cycle, being distributed in the pericentriolar material.^[8] CEP135 is required for the centriolar localization of CEP250.^[9]