CEP192

Centrosomal protein of 192 kDa, also known as Cep192, is a protein that in humans is encoded by the CEP192 gene.^[5][6] It is the homolog of the C. elegans and D. melanogaster gene SPD-2.^[7]

PDBHuman UniProt search: PDBe RCSB

AliasesCEP192, PPP1R62, centrosomal protein 192

External IDsOMIM: 616426; MGI: 1918049; HomoloGene: 73526; GeneCards: CEP192; OMA:CEP192 - orthologs

Chr.Chromosome 18 (human)^[1]

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CEP192
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4N7Z
Identifiers
Aliases	CEP192, PPP1R62, centrosomal protein 192
External IDs	OMIM: 616426; MGI: 1918049; HomoloGene: 73526; GeneCards: CEP192; OMA:CEP192 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21 Start 12,991,362 bp[1] End 13,125,052 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1- E2 Start 67,933,177 bp[2] End 68,018,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone gonad granulocyte Achilles tendon testicle right testis left testis secondary oocyte mucosa of transverse colon sperm Top expressed in genital tubercle tail of embryo hand spermatocyte secondary oocyte superior cervical ganglion epiblast zygote ventricular zone maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase binding protein binding Cellular component centriole centrosome pericentriolar material cytoskeleton cytoplasm cytosol Biological process negative regulation of phosphatase activity G2/M transition of mitotic cell cycle ciliary basal body-plasma membrane docking regulation of G2/M transition of mitotic cell cycle protein localization to centrosome centrosome-templated microtubule nucleation mitotic spindle assembly response to bacterium centrosome duplication spindle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55125 70799 Ensembl ENSG00000101639 ENSMUSG00000024542 UniProt Q8TEP8 n/a RefSeq (mRNA) NM_018069 NM_032142 NM_027556 RefSeq (protein) NP_115518 n/a Location (UCSC) Chr 18: 12.99 – 13.13 Mb Chr 18: 67.93 – 68.02 Mb PubMed search [3] [4]
Wikidata
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Cep192 is a major regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells.^[7] It stimulates the formation of the scaffolding upon which gamma tubulin ring complexes and other proteins involved in microtubule nucleation and spindle assembly become functional during mitosis.^[8]