CEP63

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Centrosomal protein of 63 kDa is a protein that in humans is encoded by the CEP63 gene.[5][6] Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

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CEP63
Identifiers
AliasesCEP63, SCKL6, centrosomal protein 63
External IDsOMIM: 614724; MGI: 2158560; HomoloGene: 11861; GeneCards: CEP63; OMA:CEP63 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081122
NM_001301689

RefSeq (protein)
Location (UCSC)Chr 3: 134.49 – 134.59 MbChr 9: 102.46 – 102.5 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.[6] Recent computational analysis revealed pathogenic property of L61P point mutation in CEP63 protein that affected its native structural conformation.[7]

Interactions

CEP63 has been shown to interact with DISC1,[8] CEP152 and CDK1.[7]

References

Further reading

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