Centrin 1

Centrin-1 is a protein that in humans is encoded by the CETN1 gene.^[5][6] It belongs to the centrin family of proteins.

AliasesCETN1, CEN1, CETN, centrin 1

External IDsOMIM: 603187; MGI: 1347086; HomoloGene: 105668; GeneCards: CETN1; OMA:CETN1 - orthologs

Chr.Chromosome 18 (human)^[1]

End582,114 bp^[1]

Quick facts CETN1, Identifiers ...

CETN1
Identifiers
Aliases	CETN1, CEN1, CETN, centrin 1
External IDs	OMIM: 603187; MGI: 1347086; HomoloGene: 105668; GeneCards: CETN1; OMA:CETN1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.32 Start 580,380 bp[1] End 582,114 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 9,615,524 bp[2] End 9,619,478 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle human musculoskeletal system muscular system muscle muscle skeletal muscle lower limb muscles Top expressed in spermatid spermatocyte seminiferous tubule lumbar subsegment of spinal cord motor neuron tibiofemoral joint submandibular gland spinal ganglia carotid body trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding calcium ion binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding protein binding metal ion binding Cellular component cytoplasm microtubule organizing center centrosome spindle pole cytoskeleton photoreceptor connecting cilium centriole nucleus Biological process cell cycle cellular response to heat cell division mitotic cytokinesis centriole replication regulation of centrosome duplication calcium-mediated signaling regulation of cytokinesis microtubule cytoskeleton organization nucleotide-excision repair mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1068 26369 Ensembl ENSG00000177143 ENSMUSG00000050996 UniProt Q12798 P41209 RefSeq (mRNA) NM_004066 NM_007593 RefSeq (protein) NP_004057 NP_031619 Location (UCSC) Chr 18: 0.58 – 0.58 Mb Chr 18: 9.62 – 9.62 Mb PubMed search [3] [4]
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The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle.^[6]