CGP-35348

CGP-35348
Identifiers
	IUPAC name 3-Aminopropyl(diethoxymethyl)phosphinic acid;
CAS Number	123690-79-9 ;
PubChem CID	107699;
IUPHAR/BPS	1069;
ChemSpider	96869 ;
UNII	87TI61875H;
CompTox Dashboard (EPA)	DTXSID70154064 ;
Chemical and physical data
Formula	C8H20NO4P
Molar mass	225.225 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(OCC)P(=O)(CCCN)O;
	InChI InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11) ; Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N ;
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CGP-35348 is a compound used in scientific research which acts as an antagonist at GABA_B receptors.^[1]^[2]^[3]

CAS Number

123690-79-9^Y

PubChem CID

107699

IUPHAR/BPS

1069

ChemSpider

96869^N

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CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as a GABA_B heteroreceptor antagonist. ^[4] Moreover, CGP-35348 was about threefold less potent in antagonizing gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) than baclofen and SKF-97,541.^[5]

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[2]

[3]

[4]

[5]

CGP-35348

References

Related Articles

Identifiers

IUPAC name 3-Aminopropyl(diethoxymethyl)phosphinic acid
CAS Number	123690-79-9^Y
PubChem CID	107699
IUPHAR/BPS	1069
ChemSpider	96869^N
UNII	87TI61875H
CompTox Dashboard (EPA)	DTXSID70154064
Chemical and physical data
Formula	C₈H₂₀NO₄P
Molar mass	225.225 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC(OCC)P(=O)(CCCN)O
InChI InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)^N Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N^N
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