CHL1

Neural cell adhesion molecule L1-like protein also known as close homolog of L1 (CHL1) is a protein that in humans is encoded by the CHL1 gene.^[6]

AliasesCHL1, CALL, L1CAM2, cell adhesion molecule L1 like

External IDsOMIM: 607416; MGI: 1098266; HomoloGene: 21314; GeneCards: CHL1; OMA:CHL1 - orthologs

Chr.Chromosome 3 (human)^[1]

End409,417 bp^[1]

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CHL1
Identifiers
Aliases	CHL1, CALL, L1CAM2, cell adhesion molecule L1 like
External IDs	OMIM: 607416; MGI: 1098266; HomoloGene: 21314; GeneCards: CHL1; OMA:CHL1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.3 Start 196,763 bp[1] End 409,417 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E1 Start 103,487,547 bp[2] End 103,727,172 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell superior frontal gyrus sural nerve spinal ganglia postcentral gyrus frontal pole Brodmann area 10 trigeminal ganglion middle temporal gyrus Top expressed in spermatid subiculum ventral tegmental area lobe of cerebellum lateral hypothalamus dorsomedial hypothalamic nucleus supraoptic nucleus substantia nigra cerebellar vermis ventromedial nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding Cellular component integral component of membrane membrane plasma membrane apical part of cell extracellular region dendrite extracellular exosome Biological process negative regulation of neuron apoptotic process cell differentiation cognition axon regeneration adult locomotory behavior neuron migration nervous system development multicellular organism development cell adhesion exploration behavior neuron projection development signal transduction axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10752 12661 Ensembl ENSG00000134121 ENSMUSG00000030077 UniProt O00533 P70232 RefSeq (mRNA) NM_001253387 NM_001253388 NM_006614 NM_007697 RefSeq (protein) NP_001240316 NP_001240317 NP_006605 NP_031723 Location (UCSC) Chr 3: 0.2 – 0.41 Mb Chr 6: 103.49 – 103.73 Mb PubMed search [3] [4]
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CHL1 is a cell adhesion molecule closely related to the L1. In melanocytic cells CHL1 gene expression may be regulated by MITF,^[7] and can act as a helicase protein during the interphase stage of mitosis.

The protein, however, has dynamic localisation, meaning that it has not only multiple roles in the cell, but also various locations.