CHRNA1

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene.^[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR).

AliasesCHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit

External IDsOMIM: 100690; MGI: 87885; GeneCards: CHRNA1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 2 (human)^[1]

Quick facts Identifiers, Aliases ...

CHRNA1
Identifiers
Aliases	CHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
External IDs	OMIM: 100690; MGI: 87885; GeneCards: CHRNA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZJS
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 174,747,592 bp[1] End 174,787,935 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 C3|2 43.76 cM Start 73,393,559 bp[2] End 73,410,682 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle glutes tibialis anterior muscle deltoid muscle muscle of thigh testicle triceps brachii muscle quadriceps femoris muscle vastus lateralis muscle Skeletal muscle tissue of biceps brachii Top expressed in ankle extraocular muscle ankle joint internal carotid artery soleus muscle vastus lateralis muscle temporal muscle triceps brachii muscle thoracic diaphragm sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular ligand-gated ion channel activity acetylcholine receptor activity ligand-gated ion channel activity ion channel activity acetylcholine binding acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane membrane synapse cell junction plasma membrane neuromuscular junction cell surface postsynaptic membrane acetylcholine-gated channel complex integral component of postsynaptic specialization membrane integral component of plasma membrane neuron projection Biological process muscle cell cellular homeostasis neuron cellular homeostasis regulation of membrane potential skeletal muscle contraction response to nicotine cation transport synaptic transmission, cholinergic ion transport skeletal muscle tissue growth neuromuscular synaptic transmission neuromuscular process neuromuscular junction development musculoskeletal movement signal transduction neuronal action potential regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport chemical synaptic transmission nervous system process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1134 11435 Ensembl ENSG00000138435 ENSMUSG00000027107 UniProt P02708 P04756 RefSeq (mRNA) NM_001039523 NM_000079 NM_007389 RefSeq (protein) NP_000070 NP_001034612 NP_031415 Location (UCSC) Chr 2: 174.75 – 174.79 Mb Chr 2: 73.39 – 73.41 Mb PubMed search [3] [4]
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The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, delta and epsilon subunits. The gamma sub-unit being only present in embryonic nAChR.^[6] This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]