CHRNA10

CHRNA10
Identifiers
Aliases	CHRNA10, cholinergic receptor nicotinic alpha 10 subunit
External IDs	OMIM: 606372; MGI: 3609260; HomoloGene: 56886; GeneCards: CHRNA10; OMA:CHRNA10 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	3,671,384 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	101,766,035 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; gonad; ; testicle; ; granulocyte; ; mucosa of transverse colon; ; blood; ; right lobe of liver; ; cerebellar hemisphere; ; right hemisphere of cerebellum;
	Top expressed in
	embryo; ; olfactory bulb; ; muscle of thigh; ; muscle tissue; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; blastocyst; ; spermatocyte; ; lip; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium channel activity; ion channel activity; signaling receptor binding; extracellular ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; membrane; plasma membrane; synapse; axon; cell junction; cholinergic synapse; integral component of postsynaptic specialization membrane; integral component of plasma membrane; neuron projection;
Biological process	positive regulation of cytosolic calcium ion concentration; synaptic transmission, cholinergic; ion transport; detection of mechanical stimulus involved in sensory perception of sound; regulation of cell population proliferation; calcium ion transmembrane transport; inner ear morphogenesis; calcium ion transport; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; signal transduction; ion transmembrane transport; negative regulation of ERK1 and ERK2 cascade; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	57053
	504186
	ENSG00000129749
	ENSMUSG00000066279
	Q9GZZ6
	n/a
	NM_001303034; NM_001303035; NM_020402
	NM_001081424
	NP_001289963; NP_001289964; NP_065135
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.^[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

AliasesCHRNA10, cholinergic receptor nicotinic alpha 10 subunit

External IDsOMIM: 606372; MGI: 3609260; HomoloGene: 56886; GeneCards: CHRNA10; OMA:CHRNA10 - orthologs

Chr.Chromosome 11 (human)^[1]

End3,671,384 bp^[1]

Quick facts Identifiers, Aliases ...

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This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.^[6] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.^[7]

α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.

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CHRNA10

References

External links

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