CHRNB3

CHRNB3
Identifiers
Aliases	CHRNB3, cholinergic receptor nicotinic beta 3 subunit
External IDs	OMIM: 118508; MGI: 106212; HomoloGene: 36035; GeneCards: CHRNB3; OMA:CHRNB3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,737,407 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,889,758 bp
RNA expression pattern
	Top expressed in
	testicle; ; pancreatic ductal cell; ; mucosa of ileum; ; tibialis anterior muscle; ; right testis; ; cerebellar cortex; ; cerebellar hemisphere; ; left testis; ; prefrontal cortex; ; substantia nigra;
	Top expressed in
	neural layer of retina; ; inner nuclear layer; ; ganglion cell layer; ; habenula; ; outer nuclear layer; ; ventral tegmental area; ; primary visual cortex; ; spinal ganglia; ; meninges; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	channel activity; ion channel activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; acetylcholine-gated cation-selective channel activity; transmembrane signaling receptor activity; acetylcholine binding; acetylcholine receptor activity;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; plasma membrane; synapse; cell junction; acetylcholine-gated channel complex; dopaminergic synapse; integral component of plasma membrane; neuron projection;
Biological process	response to nicotine; synaptic transmission, cholinergic; ion transport; neuromuscular synaptic transmission; signal transduction; regulation of postsynaptic membrane potential; excitatory postsynaptic potential; cation transmembrane transport; ion transmembrane transport; regulation of synaptic vesicle exocytosis; chemical synaptic transmission; regulation of membrane potential; nervous system process; protein heterooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	1142
	108043
	ENSG00000147432
	ENSMUSG00000031492
	Q05901
	Q8BMN3
	NM_000749; NM_001347717
	NM_027454; NM_173212
	NP_000740; NP_001334646
	NP_081730; NP_775304
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal acetylcholine receptor subunit beta-3 is a protein that in humans is encoded by the CHRNB3 gene.^[5]^[6] This gene has been identified as a candidate for predisposition to tobacco dependence.