CHRNG

Acetylcholine receptor subunit gamma is a protein that in humans is encoded by the CHRNG gene.^[5]

AliasesCHRNG, ACHRG, cholinergic receptor nicotinic gamma subunit

External IDsOMIM: 100730; MGI: 87895; HomoloGene: 3810; GeneCards: CHRNG; OMA:CHRNG - orthologs

Chr.Chromosome 2 (human)^[1]

End232,548,115 bp^[1]

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CHRNG
Identifiers
Aliases	CHRNG, ACHRG, cholinergic receptor nicotinic gamma subunit
External IDs	OMIM: 100730; MGI: 87895; HomoloGene: 3810; GeneCards: CHRNG; OMA:CHRNG - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,539,692 bp[1] End 232,548,115 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C5|1 44.07 cM Start 87,132,379 bp[2] End 87,140,416 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh cerebellar vermis glutes synovial joint human penis periodontal fiber skeletal muscle tissue sural nerve seminal vesicula Top expressed in lens internal carotid artery mylohyoid muscle tongue muscle erector spinae muscles tongue Psoas zygote shoulder psoas major muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function channel activity acetylcholine binding acetylcholine receptor activity ion channel activity protein binding extracellular ligand-gated ion channel activity ligand-gated ion channel activity acetylcholine-gated cation-selective channel activity transmembrane signaling receptor activity Cellular component integral component of membrane acetylcholine-gated channel complex postsynaptic membrane membrane plasma membrane synapse integral component of plasma membrane cell junction neuron projection Biological process muscle contraction response to nicotine synaptic transmission, cholinergic ion transport cation transmembrane transport neuromuscular synaptic transmission signal transduction regulation of postsynaptic membrane potential excitatory postsynaptic potential ion transmembrane transport chemical synaptic transmission regulation of membrane potential nervous system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1146 11449 Ensembl ENSG00000196811 ENSMUSG00000026253 UniProt P07510 P04760 RefSeq (mRNA) NM_005199 NM_009604 RefSeq (protein) NP_005190 n/a Location (UCSC) Chr 2: 232.54 – 232.55 Mb Chr 1: 87.13 – 87.14 Mb PubMed search [3] [4]
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It is one of the subunits that compose the nicotinic acetylcholine receptor (nAChR). It is a pentameric ionotropic receptor composed of five of four different subunits : two alpha (α), one beta (β), one delta (δ) and either one gamma (γ) or one epsilon (ε).

Two forms of AChR are found in mammalian skeletal muscle cells. The mature form, containing the epsilon subunit, which is specific to this mature AChR subtype^[6], is predominant in innervated adult muscle and the embryonic form, containing gamma is present in fetal and denervated muscle.^[7]

This switch is mediated by Neuregulin 1 (acetylcholine receptor-inducing activity).^[5]