CIAO1

CIAO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FM0
Identifiers
Aliases	CIAO1, CIA1, WDR39, cytosolic iron-sulfur assembly component 1
External IDs	OMIM: 604333; MGI: 1346998; HomoloGene: 55850; GeneCards: CIAO1; OMA:CIAO1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	96,274,173 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,089,736 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; granulocyte; ; ganglionic eminence; ; cerebellar hemisphere; ; ventricular zone; ; body of pancreas; ; right frontal lobe; ; putamen; ; nucleus accumbens;
	Top expressed in
	right ventricle; ; right kidney; ; muscle of thigh; ; interventricular septum; ; medial ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; human kidney; ; lip; ; adrenal gland; ; seminal vesicula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	CIA complex; MMXD complex; cytoplasm;
Biological process	regulation of transcription by RNA polymerase II; iron-sulfur cluster assembly; positive regulation of cell population proliferation; chromosome segregation; protein maturation by iron-sulfur cluster transfer;
	Sources:Amigo / QuickGO
Orthologs
	9391
	26371
	ENSG00000144021
	ENSMUSG00000003662
	O76071
	Q99KN2
	NM_004804
	NM_025296
	NP_004795
	NP_079572
	Wikidata
View/Edit Human	View/Edit Mouse

Probable cytosolic iron-sulfur protein assembly protein CIAO1 is a protein that in humans is encoded by the CIAO1 gene.^[5]^[6]^[7] CIAO1 forms a complex with FAM96B, MMS19, the co-chaperone HSC20 and the scaffold protein ISCU in order to assist iron-sulfur cluster incorporation into cytoplasmic and nuclear iron-sulfur proteins.^[8]^[9]