CIRBP

Cold-inducible RNA-binding protein is a protein that in humans is encoded by the CIRBP gene.^[5][6][7] The cold inducible RNA-binding protein CIRBP plays a critical role in controlling the cellular response upon confronting a variety of cellular stresses, including short wavelength ultraviolet light, hypoxia, and hypothermia. It is thought to be involved in DNA repair.^[8]

PDBOrtholog search: PDBe RCSB

AliasesCIRBP, CIRP, cold inducible RNA binding protein

External IDsOMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs

Chr.Chromosome 19 (human)^[1]

Quick facts Available structures, PDB ...

CIRBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X5S
Identifiers
Aliases	CIRBP, CIRP, cold inducible RNA binding protein
External IDs	OMIM: 602649; MGI: 893588; HomoloGene: 980; GeneCards: CIRBP; OMA:CIRBP - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 1,259,384 bp[1] End 1,274,880 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 80,165,985 bp[2] End 80,172,786 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia corpus epididymis caput epididymis parietal pleura germinal epithelium right hemisphere of cerebellum right uterine tube anterior pituitary middle temporal gyrus left ovary Top expressed in neural layer of retina lip cerebellar cortex molar ventricular zone spermatocyte superior frontal gyrus primary visual cortex dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation repressor activity nucleic acid binding protein binding small ribosomal subunit rRNA binding mRNA 3'-UTR binding RNA binding poly(U) RNA binding Cellular component cytoplasm cytoplasmic stress granule nucleolus nucleus nucleoplasm spliceosomal complex ribonucleoprotein complex Biological process stress granule assembly response to cold mRNA stabilization response to UV positive regulation of translation negative regulation of translation positive regulation of mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1153 12696 Ensembl ENSG00000099622 ENSMUSG00000045193 UniProt Q14011 Q53XX5 P60824 RefSeq (mRNA) NM_001280 NM_001300815 NM_001300829 NM_007705 RefSeq (protein) NP_001271 NP_001287744 NP_001287758 NP_001271.1 NP_031731 NP_001366350 NP_001366351 NP_001366352 NP_001366353 NP_001366354 Location (UCSC) Chr 19: 1.26 – 1.27 Mb Chr 10: 80.17 – 80.17 Mb PubMed search [3] [4]
Wikidata
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