CIZ1
Protein-coding gene in humans
From Wikipedia, the free encyclopedia
Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.[5][6]
| CIZ1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CIZ1, LSFR1, NP94, ZNF356, CDKN1A interacting zinc finger protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 611420; MGI: 1920234; HomoloGene: 8112; GeneCards: CIZ1; OMA:CIZ1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
The protein encoded by this gene is a zinc finger DNA binding transcription factor that interacts with CIP1 (p21 / CDKN1A), part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1.[6]
Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a biomarker for early detection of lung cancer.[7]
Ciz1 mutant mice
Aged (18-mo-old) Ciz1-/- mice have increased neuronal DNA double-strand breaks that likely contributed to their loss of neurons and cognitive decline with age.[8] Embryonic fibroblasts from Ciz1-/- mice show abnormal sensitivity to γ-irradiation with persistent DNA breaks, aberrant cell cycle progression and increased apoptosis.[8]
