Keratin 4

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.^[5][6]

AliasesKRT4, CK-4, CK4, CYK4, K4, WSN1, Keratin 4

External IDsOMIM: 123940; MGI: 96701; HomoloGene: 20523; GeneCards: KRT4; OMA:KRT4 - orthologs

Chr.Chromosome 12 (human)^[1]

End52,814,116 bp^[1]

Quick facts KRT4, Identifiers ...

KRT4
Identifiers
Aliases	KRT4, CK-4, CK4, CYK4, K4, WSN1, Keratin 4
External IDs	OMIM: 123940; MGI: 96701; HomoloGene: 20523; GeneCards: KRT4; OMA:KRT4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 52,806,549 bp[1] End 52,814,116 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F2|15 57.13 cM Start 101,826,970 bp[2] End 101,833,170 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of pharynx oral cavity body of tongue palpebral conjunctiva superior surface of tongue buccal mucosa cell amniotic fluid nasal epithelium gums epithelium of nasopharynx Top expressed in superior surface of tongue esophagus conjunctival fornix condyle molar fossa cornea ciliary body corneal stroma stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural molecule activity Cellular component cell surface intermediate filament cytoskeleton keratin filament intermediate filament nucleus cytosol Biological process epithelial cell differentiation cytoskeleton organization negative regulation of epithelial cell proliferation keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3851 16682 Ensembl ENSG00000170477 ENSMUSG00000059668 UniProt P19013 P07744 RefSeq (mRNA) NM_002272 NM_008475 RefSeq (protein) NP_002263 NP_032501 Location (UCSC) Chr 12: 52.81 – 52.81 Mb Chr 15: 101.83 – 101.83 Mb PubMed search [3] [4]
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Keratin 4 is a type II cytokeratin. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.^[7]