CLCA1

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.^[5][6]

AliasesCLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1

External IDsOMIM: 603906; MGI: 1346342; HomoloGene: 984; GeneCards: CLCA1; OMA:CLCA1 - orthologs

Chr.Chromosome 1 (human)^[1]

End86,500,259 bp^[1]

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CLCA1
Identifiers
Aliases	CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1
External IDs	OMIM: 603906; MGI: 1346342; HomoloGene: 984; GeneCards: CLCA1; OMA:CLCA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,468,368 bp[1] End 86,500,259 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H2|3 69.26 cM Start 144,709,578 bp[2] End 144,738,537 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum mucosa of sigmoid colon jejunal mucosa mucosa of transverse colon rectum duodenum cecum appendix pancreatic ductal cell epithelium of colon Top expressed in left colon intestinal villus cervix pyloric antrum ileum duodenum mucous cell of stomach crypt of lieberkuhn of small intestine epithelium of small intestine jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding peptidase activity hydrolase activity chloride channel activity metallopeptidase activity metalloendopeptidase activity intracellular calcium activated chloride channel activity Cellular component extracellular region integral component of membrane integral component of plasma membrane microvillus zymogen granule membrane membrane plasma membrane secretory granule extracellular space Biological process calcium ion transport proteolysis chloride transport ion transport ion transmembrane transport cellular response to hypoxia chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1179 23844 Ensembl ENSG00000016490 ENSMUSG00000028255 UniProt A8K7I4 Q9D7Z6 RefSeq (mRNA) NM_001285 NM_017474 RefSeq (protein) NP_001276 NP_059502 Location (UCSC) Chr 1: 86.47 – 86.5 Mb Chr 3: 144.71 – 144.74 Mb PubMed search [3] [4]
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This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.^[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.^[7]