CLCA2

Chloride channel accessory 2 is a protein that in humans is encoded by the CLCA2 gene.^[5]

AliasesCLCA2, CACC, CACC3, CLCRG2, CaCC-3, chloride channel accessory 2

External IDsOMIM: 604003; MGI: 2139758; HomoloGene: 4765; GeneCards: CLCA2; OMA:CLCA2 - orthologs

Chr.Chromosome 1 (human)^[1]

End86,456,553 bp^[1]

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CLCA2
Identifiers
Aliases	CLCA2, CACC, CACC3, CLCRG2, CaCC-3, chloride channel accessory 2
External IDs	OMIM: 604003; MGI: 2139758; HomoloGene: 4765; GeneCards: CLCA2; OMA:CLCA2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,424,171 bp[1] End 86,456,553 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 144,776,024 bp[2] End 144,805,204 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium human penis skin of thigh vulva oral cavity hair follicle skin of arm bronchial epithelial cell skin of hip mucosa of pharynx Top expressed in skin of external ear esophagus lower jaw skin of back incisor mandibular molars skin of abdomen lip embryo Meckel's cartilage More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding peptidase activity ligand-gated ion channel activity hydrolase activity metallopeptidase activity chloride channel activity metalloendopeptidase activity intracellular calcium activated chloride channel activity Cellular component integral component of membrane membrane integral component of plasma membrane extracellular region cell junction basal plasma membrane nucleus cytosol plasma membrane nuclear membrane Biological process chloride transmembrane transport ion transport proteolysis cell adhesion chloride transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9635 229933 Ensembl ENSG00000137975 ENSMUSG00000036960 UniProt Q9UQC9 Q8BG22 RefSeq (mRNA) NM_006536 NM_178697 RefSeq (protein) NP_006527 NP_848812 Location (UCSC) Chr 1: 86.42 – 86.46 Mb Chr 3: 144.78 – 144.81 Mb PubMed search [3] [4]
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The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer.^[5] Protein structure prediction methods suggest the N-terminal region of CLCA2 protein is a zinc metalloprotease.^[6]