CLCF1

CLCF1
Identifiers
Aliases	CLCF1, BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6, cardiotrophin-like cytokine factor 1, cardiotrophin like cytokine factor 1
External IDs	OMIM: 607672; MGI: 1930088; HomoloGene: 8299; GeneCards: CLCF1; OMA:CLCF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,374,177 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	4,273,544 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; testicle; ; body of uterus; ; gallbladder; ; cartilage tissue; ; gastric mucosa; ; granulocyte; ; canal of the cervix; ; right uterine tube; ; stromal cell of endometrium;
	Top expressed in
	spleen; ; bone marrow; ; adrenal gland; ; islet of Langerhans; ; embryo; ; embryo; ; thymus; ; lip; ; urinary bladder; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; protein binding; protein heterodimerization activity; ciliary neurotrophic factor receptor binding; growth factor activity; signaling receptor binding;
Cellular component	CNTFR-CLCF1 complex; CRLF-CLCF1 complex; extracellular region; intracellular anatomical structure; extracellular space;
Biological process	negative regulation of neuron apoptotic process; positive regulation of isotype switching to IgE isotypes; receptor signaling pathway via JAK-STAT; positive regulation of astrocyte differentiation; positive regulation of immunoglobulin production; cell surface receptor signaling pathway; positive regulation of B cell proliferation; positive regulation of cell population proliferation; B cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23529
	56708
	ENSG00000175505
	ENSMUSG00000040663
	Q9UBD9
	Q9QZM3
	NM_013246; NM_001166212
	NM_019952; NM_001310038; NM_001310039
	NP_001159684; NP_037378
	NP_001296967; NP_001296968; NP_064336
	Wikidata
View/Edit Human	View/Edit Mouse

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.^[5]