CLCNKB

Chloride channel Kb, also known as CLCNKB, is a protein which in humans is encoded by the CLCNKB gene.^[5][6]

AliasesCLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb

External IDsOMIM: 602023; MGI: 1329026; HomoloGene: 65; GeneCards: CLCNKB; OMA:CLCNKB - orthologs

Chr.Chromosome 1 (human)^[1]

End16,057,311 bp^[1]

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CLCNKB
Identifiers
Aliases	CLCNKB, CLCKB, ClC-K2, ClC-Kb, chloride voltage-gated channel Kb
External IDs	OMIM: 602023; MGI: 1329026; HomoloGene: 65; GeneCards: CLCNKB; OMA:CLCNKB - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.13 Start 16,040,252 bp[1] End 16,057,311 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 141,111,921 bp[2] End 141,126,035 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla parotid gland sperm right lobe of thyroid gland left lobe of thyroid gland human kidney apex of heart oocyte cerebellar hemisphere right hemisphere of cerebellum Top expressed in right kidney distal tubule outer renal medulla human kidney connecting tubule Ascending limb of loop of Henle stria vascularis inner renal medulla inner stripe of outer renal medulla saccule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding voltage-gated ion channel activity chloride channel activity voltage-gated chloride channel activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane chloride channel complex membrane Biological process ion transmembrane transport chloride transport excretion regulation of ion transmembrane transport ion transport transmembrane transport chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1188 12733 Ensembl ENSG00000184908 ENSMUSG00000033770 UniProt P51801 Q9WUB7 RefSeq (mRNA) NM_000085 NM_001165945 NM_001146307 NM_024412 RefSeq (protein) NP_000076 NP_001159417 NP_001139779 NP_077723 Location (UCSC) Chr 1: 16.04 – 16.06 Mb Chr 4: 141.11 – 141.13 Mb PubMed search [3] [4]
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Chloride channel Kb (CLCNKB) is a member of the CLC family of voltage-gated chloride channels, which comprises at least 9 mammalian chloride channels.^[7] Each is believed to have 12 transmembrane domains and intracellular N and C termini. Mutations in CLCNKB result in the autosomal recessive Type III Bartter syndrome.^[8] CLCNKA and CLCNKB are closely related (94% sequence identity), tightly linked (separated by 11 kb of genomic sequence) and are both expressed in mammalian kidney.^[5]