CLDN5

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[5][6][7] It belongs to the group of claudins.

AliasesCLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
End19,527,545 bp[1]
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CLDN5
Identifiers
AliasesCLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
External IDsOMIM: 602101; MGI: 1276112; HomoloGene: 2459; GeneCards: CLDN5; OMA:CLDN5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003277
NM_001130861
NM_001363066
NM_001363067

NM_013805

RefSeq (protein)

NP_001124333
NP_003268
NP_001349995
NP_001349996

NP_038833

Location (UCSC)Chr 22: 19.52 – 19.53 MbChr 16: 18.6 – 18.6 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[7]

Interactions

CLDN5 has been shown to interact with CLDN1[8] and CLDN3.[8]

References

Further reading

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