CLDN7

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene.^[5][6] It belongs to the group of claudins.

AliasesCLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7

External IDsOMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs

Chr.Chromosome 17 (human)^[1]

End7,263,983 bp^[1]

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CLDN7
Identifiers
Aliases	CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDs	OMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,259,903 bp[1] End 7,263,983 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,855,605 bp[2] End 69,858,711 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum rectum right uterine tube olfactory zone of nasal mucosa minor salivary glands body of pancreas left lobe of thyroid gland islet of Langerhans right lobe of thyroid gland Top expressed in crypt of lieberkuhn of small intestine left colon migratory enteric neural crest cell ileum duodenum yolk sac medullary collecting duct jejunum mucosa of urinary bladder transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding protein binding cell adhesion molecule binding Cellular component bicellular tight junction cell junction basolateral plasma membrane membrane lateral plasma membrane integral component of membrane apicolateral plasma membrane plasma membrane Biological process negative regulation of protein homooligomerization negative regulation of cell adhesion positive regulation of cell motility negative regulation of apoptotic process positive regulation of cell population proliferation calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1366 53624 Ensembl ENSG00000181885 ENSG00000288292 ENSMUSG00000018569 UniProt O95471 Q9Z261 RefSeq (mRNA) NM_001307 NM_001185022 NM_001185023 NM_001193619 NM_016887 RefSeq (protein) NP_001171951 NP_001171952 NP_001298 NP_001180548 NP_058583 Location (UCSC) Chr 17: 7.26 – 7.26 Mb Chr 11: 69.86 – 69.86 Mb PubMed search [3] [4]
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Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM]^[6]