CLIC1

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesCLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1

External IDsOMIM: 602872; MGI: 2148924; HomoloGene: 20343; GeneCards: CLIC1; OMA:CLIC1 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts Available structures, PDB ...

CLIC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K0M, 1K0N, 1K0O, 1RK4, 3O3T, 3P8W, 3P90, 3QR6, 3SWL, 3TGZ, 3UVH, 4IQA, 4JZQ, 4K0G, 4K0N
Identifiers
Aliases	CLIC1, G6, NCC27, chloride intracellular channel 1, CL1C1, CLCNL1
External IDs	OMIM: 602872; MGI: 2148924; HomoloGene: 20343; GeneCards: CLIC1; OMA:CLIC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,730,581 bp[1] End 31,739,763 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 18.58 cM Start 35,268,942 bp[2] End 35,277,725 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte mucosa of transverse colon rectum gallbladder islet of Langerhans olfactory zone of nasal mucosa placenta right lung Top expressed in corneal stroma granulocyte superior surface of tongue thymus endothelial cell of lymphatic vessel pyloric antrum lip mucous cell of stomach dermis cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity protein binding chloride channel activity cadherin binding glutathione transferase activity Cellular component cytoplasm integral component of membrane vesicle nuclear membrane blood microparticle nuclear envelope membrane plasma membrane chloride channel complex mitochondrion brush border perinuclear region of cytoplasm extracellular exosome nucleus extracellular space Biological process regulation of ion transmembrane transport ion transport regulation of cell cycle regulation of mitochondrial membrane potential positive regulation of osteoblast differentiation chloride transport platelet aggregation signal transduction chloride transmembrane transport glutathione metabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1192 114584 Ensembl ENSG00000213719 ENSG00000223639 ENSG00000226248 ENSG00000226651 ENSG00000226417 ENSG00000230685 ENSG00000206394 ENSMUSG00000007041 UniProt O00299 Q9Z1Q5 RefSeq (mRNA) NM_001288 NM_001287593 NM_001287594 NM_033444 RefSeq (protein) NP_001274522 NP_001274523 NP_001279 NP_254279 Location (UCSC) Chr 6: 31.73 – 31.74 Mb Chr 17: 35.27 – 35.28 Mb PubMed search [3] [4]
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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.^[6]

CLIC1 is highly expressed in murine and human microglia, the innate immune cells of the central nervous system. It regulates the motility and ramification of microglial processes, which are essential for continuous surveillance of the brain parenchyma. CLIC1 is also important for the inflammatory potential of microglia by controlling the NLRP3-dependent release of interleukin-1β. Contrary to its name, these functions are not mediated by CLIC1's ion channel activity but depend on its scaffold and enzymatic properties.^[7]