CLIC2

Chloride intracellular channel protein 2 is a protein that in humans is encoded by the CLIC2 gene.^[3][4]

PDBHuman UniProt search: PDBe RCSB

AliasesCLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2

External IDsOMIM: 300138; HomoloGene: 48010; GeneCards: CLIC2; OMA:CLIC2 - orthologs

Chr.X chromosome (human)^[1]

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CLIC2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2PER, 2R4V, 2R5G
Identifiers
Aliases	CLIC2, CLIC2b, MRXS32, XAP121, chloride intracellular channel 2, CLCNL2
External IDs	OMIM: 300138; HomoloGene: 48010; GeneCards: CLIC2; OMA:CLIC2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,276,211 bp[1] End 155,334,657 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon right lung spleen upper lobe of left lung gallbladder superficial temporal artery lymph node left lobe of thyroid gland right lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glutathione transferase activity voltage-gated ion channel activity glutathione peroxidase activity protein binding chloride channel activity Cellular component cytoplasm integral component of membrane membrane intracellular anatomical structure chloride channel complex nucleus Biological process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of ion transmembrane transport ion transport negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of binding chloride transport regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum signal transduction cellular oxidant detoxification glutathione metabolic process chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1193 n/a Ensembl ENSG00000155962 n/a UniProt O15247 n/a RefSeq (mRNA) NM_001289 n/a RefSeq (protein) NP_001280 n/a Location (UCSC) Chr X: 155.28 – 155.33 Mb n/a PubMed search [2] n/a
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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.^[4]