CLK1

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesCLK1, CLK, CLK/STY, STY, CDC like kinase 1
Quick facts Available structures, PDB ...
CLK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK1, CLK, CLK/STY, STY, CDC like kinase 1
External IDsOMIM: 601951; MGI: 107403; HomoloGene: 101535; GeneCards: CLK1; OMA:CLK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024646
NM_001162407
NM_004071

NM_001042634
NM_009905

RefSeq (protein)

NP_001155879
NP_004062

NP_001036099

Location (UCSC)Chr 2: 200.85 – 200.86 MbChr 1: 58.45 – 58.46 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the cell nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine-rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection.[6]

Interactions

CLK1 has been shown to interact with ASF/SF2.[7][8]

References

Further reading

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