CNOT3

CNOT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4C0D, 4C0G, 5FU6, 5FU7
Identifiers
Aliases	CNOT3, LENG2, NOT3, NOT3H, CCR4-NOT transcription complex subunit 3, IDDSADF
External IDs	OMIM: 604910; MGI: 2385261; HomoloGene: 133900; GeneCards: CNOT3; OMA:CNOT3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,155,681 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,661,109 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; pituitary gland; ; granulocyte; ; right uterine tube; ; anterior pituitary; ; right hemisphere of cerebellum; ; ventricular zone; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; blood;
	Top expressed in
	zygote; ; genital tubercle; ; tail of embryo; ; granulocyte; ; ventricular zone; ; yolk sac; ; neural layer of retina; ; lip; ; hand; ; Rostral migratory stream;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; CCR4-NOT complex; cytosol; P-body; nucleus; CCR4-NOT core complex;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; multicellular organism development; gene silencing; negative regulation of translation; regulation of stem cell population maintenance; regulation of transcription, DNA-templated; trophectodermal cell differentiation; regulation of translation; transcription, DNA-templated; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	4849
	232791
ENSG00000088038; ENSG00000277600; ENSG00000277114; ENSG00000274616; ENSG00000275979;
	ENSG00000277615; ENSG00000276082; ENSG00000274176; ENSG00000274941; ENSG00000273943
	ENSMUSG00000035632
	O75175
	Q8K0V4
	NM_014516
	NM_146176
	NP_055331
	NP_666288
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 3 is a protein that in humans is encoded by the CNOT3 gene.^[5]^[6]^[7] It is a subunit of the CCR4-Not deadenylase complex.