CNOT6

CCR4-NOT transcription complex subunit 6 is a protein that in humans is encoded by the CNOT6 gene.^[5][6]

AliasesCNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6

External IDsOMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs

Chr.Chromosome 5 (human)^[1]

End180,578,358 bp^[1]

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CNOT6
Identifiers
Aliases	CNOT6, CCR4, Ccr4a, CCR4-NOT transcription complex subunit 6
External IDs	OMIM: 608951; MGI: 2144529; HomoloGene: 69187; GeneCards: CNOT6; OMA:CNOT6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 180,494,379 bp[1] End 180,578,358 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.2 Start 49,562,330 bp[2] End 49,603,550 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell cerebellar vermis ganglionic eminence ventricular zone retinal pigment epithelium epithelium of nasopharynx trabecular bone amniotic fluid bronchial epithelial cell Top expressed in retinal pigment epithelium saccule otic vesicle ciliary body ureter medial ganglionic eminence cumulus cell superior cervical ganglion trigeminal ganglion otic placode More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity exoribonuclease activity metal ion binding protein binding RNA binding nuclease activity exonuclease activity hydrolase activity 3'-5'-exoribonuclease activity Cellular component cytoplasm cytosol membrane CCR4-NOT complex nucleus Biological process regulation of transcription, DNA-templated nucleic acid phosphodiester bond hydrolysis transcription, DNA-templated positive regulation of cytoplasmic mRNA processing body assembly gene silencing by miRNA positive regulation of cell population proliferation exonucleolytic catabolism of deadenylated mRNA gene silencing nuclear-transcribed mRNA catabolic process, no-go decay regulation of translation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest RNA phosphodiester bond hydrolysis, exonucleolytic nuclear-transcribed mRNA poly(A) tail shortening Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57472 104625 Ensembl ENSG00000113300 ENSMUSG00000020362 UniProt Q9ULM6 Q8K3P5 RefSeq (mRNA) NM_001303241 NM_015455 NM_001370472 NM_001370473 NM_001370474 NM_001290741 NM_212484 NM_001363356 NM_001363357 RefSeq (protein) NP_001290170 NP_001357401 NP_001357402 NP_001357403 NP_001277670 NP_997649 NP_001350285 NP_001350286 Location (UCSC) Chr 5: 180.49 – 180.58 Mb Chr 11: 49.56 – 49.6 Mb PubMed search [3] [4]
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The protein encoded by this gene is a subunit of the CCR4-Not transcriptional regulation and deadenylase complex. The encoded protein has a 3'-5' exonuclease activity and prefers polyadenylated substates.^[6]