CNOT8

CNOT8
Identifiers
Aliases	CNOT8, CAF1, CALIF, Caf1b, POP2, hCAF1, CCR4-NOT transcription complex subunit 8
External IDs	OMIM: 603731; MGI: 1916375; HomoloGene: 48304; GeneCards: CNOT8; OMA:CNOT8 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	154,876,792 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,009,420 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; sperm; ; right lung; ; ganglionic eminence; ; Achilles tendon; ; granulocyte; ; rectum; ; upper lobe of left lung; ; ventricular zone;
	Top expressed in
	secondary oocyte; ; neural layer of retina; ; thymus; ; zygote; ; medial ganglionic eminence; ; granulocyte; ; ventricular zone; ; primary oocyte; ; neural tube; ; morula;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	poly(A)-specific ribonuclease activity; 3'-5'-exoribonuclease activity; DNA-binding transcription factor activity; metal ion binding; protein binding; RNA binding; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity;
Cellular component	cytoplasm; cytosol; CCR4-NOT complex; intracellular anatomical structure; nucleus; P-body; CCR4-NOT core complex;
Biological process	regulation of transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; positive regulation of mRNA catabolic process; transcription, DNA-templated; gene silencing by miRNA; positive regulation of cell population proliferation; exonucleolytic catabolism of deadenylated mRNA; gene silencing; regulation of translation; negative regulation of cell population proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	9337
	69125
	ENSG00000155508
	ENSMUSG00000020515
	Q9UFF9
	Q9D8X5
NM_001301073; NM_001301074; NM_001301075; NM_001301077; NM_001301080;
	NM_001301082; NM_001301083; NM_001301086; NM_004779
	NM_026949; NM_001356477; NM_001363084; NM_001363085; NM_001363086
NP_001288002; NP_001288003; NP_001288004; NP_001288006; NP_001288009;
	NP_001288011; NP_001288012; NP_001288015; NP_004770
	NP_081225; NP_001343406; NP_001350013; NP_001350014; NP_001350015
	Wikidata
View/Edit Human	View/Edit Mouse

CCR4-NOT transcription complex subunit 8 is a protein that in humans is encoded by the CNOT8 gene.^[5]^[6]^[7] It is a subunit of the CCR4-Not deadenylase complex.