Cofactor of BRCA1

NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660).^[6] COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of BRCA1 as bait.^[7]

Cofactor of BRCA1 has been shown to interact with:

• BRCA1^[8]
• C-Fos,^[9]
• C-jun,^[9]
• Estrogen receptor alpha,^[10]
• RDBP,^[11][12] and
• TH1L.^[11][13]