COG2

Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene.^[5][6]

AliasesCOG2, LDLC, component of oligomeric golgi complex 2, CDG2Q

External IDsOMIM: 606974; MGI: 1923582; HomoloGene: 7206; GeneCards: COG2; OMA:COG2 - orthologs

Chr.Chromosome 1 (human)^[1]

End230,693,982 bp^[1]

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COG2
Identifiers
Aliases	COG2, LDLC, component of oligomeric golgi complex 2, CDG2Q
External IDs	OMIM: 606974; MGI: 1923582; HomoloGene: 7206; GeneCards: COG2; OMA:COG2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.2 Start 230,642,481 bp[1] End 230,693,982 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 E2 Start 125,247,506 bp[2] End 125,278,747 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum right hemisphere of cerebellum right adrenal cortex pancreatic ductal cell islet of Langerhans gonad left adrenal gland left adrenal cortex granulocyte tibialis anterior muscle Top expressed in yolk sac lens granulocyte spermatocyte right kidney neural layer of retina epithelium of stomach muscle of thigh proximal tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein-containing complex binding Cellular component Golgi transport complex cytosol Golgi membrane Golgi stack Golgi apparatus membrane trans-Golgi network membrane Biological process protein transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Golgi organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22796 76332 Ensembl ENSG00000135775 ENSMUSG00000031979 UniProt Q14746 Q921L5 RefSeq (mRNA) NM_007357 NM_001145036 NM_029746 RefSeq (protein) NP_001138508 NP_031383 NP_084022 Location (UCSC) Chr 1: 230.64 – 230.69 Mb Chr 8: 125.25 – 125.28 Mb PubMed search [3] [4]
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Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).^[6]