COMMD1

COMMD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H2M
Identifiers
Aliases	COMMD1, C2orf5, MURR1, copper metabolism domain containing 1
External IDs	OMIM: 607238; MGI: 109474; HomoloGene: 17604; GeneCards: COMMD1; OMA:COMMD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	62,147,247 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	22,932,382 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; tibialis anterior muscle; ; cardiac muscle tissue of right atrium; ; right ventricle; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; right auricle of heart; ; vena cava; ; skin of arm; ; mucosa of ileum;
	Top expressed in
	embryo; ; embryo; ; spermatocyte; ; right kidney; ; ventricular zone; ; external carotid artery; ; intercostal muscle; ; epiblast; ; medullary collecting duct; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; phosphatidylinositol-3,5-bisphosphate binding; metal ion binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidic acid binding; protein binding; identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; copper ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding;
Cellular component	cytoplasm; recycling endosome; endosome; membrane; Cul2-RING ubiquitin ligase complex; early endosome; endosome membrane; cytoplasmic vesicle; nucleus; nucleoplasm; cytosol;
Biological process	negative regulation of sodium ion transmembrane transport; regulation of transcription, DNA-templated; transcription, DNA-templated; negative regulation of protein localization to cell surface; plasma membrane to endosome transport; regulation of proteasomal ubiquitin-dependent protein catabolic process; protein transport; negative regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; Golgi to plasma membrane transport; post-translational protein modification; copper ion homeostasis; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	150684
	17846
	ENSG00000173163
	ENSMUSG00000051355
	Q8N668
	Q8K4M5
	NM_152516; NM_001321781; NM_001321782; NM_001371765
	NM_144514; NM_001361661
	NP_001308710; NP_001308711; NP_689729; NP_001358694
	NP_653097; NP_001348590
	Wikidata
View/Edit Human	View/Edit Mouse

COMM domain-containing protein 1 is a protein that is encoded by the COMMD1 gene in humans. It was originally regarded as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab^[5]^[6]^[7]