COQ2

Para-hydroxybenzoate—polyprenyltransferase, mitochondrial is an enzyme that in humans is encoded by the COQ2 gene.^[5][6]

AliasesCOQ2, CL640, COQ10D1, MSA1, PHB:PPT, coenzyme Q2, polyprenyltransferase

External IDsOMIM: 609825; MGI: 1919133; HomoloGene: 69192; GeneCards: COQ2; OMA:COQ2 - orthologs

Chr.Chromosome 4 (human)^[1]

End83,284,914 bp^[1]

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COQ2
Identifiers
Aliases	COQ2, CL640, COQ10D1, MSA1, PHB:PPT, coenzyme Q2, polyprenyltransferase
External IDs	OMIM: 609825; MGI: 1919133; HomoloGene: 69192; GeneCards: COQ2; OMA:COQ2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.23 Start 83,261,536 bp[1] End 83,284,914 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E4 Start 100,802,589 bp[2] End 100,823,006 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis gingival epithelium vastus lateralis muscle monocyte body of tongue triceps brachii muscle muscle of thigh glutes deltoid muscle Top expressed in left ventricle interventricular septum proximal tubule quadriceps femoris muscle right kidney muscle of thigh upper arm neural layer of retina muscle tissue visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity 4-hydroxybenzoate nonaprenyltransferase activity prenyltransferase activity 4-hydroxybenzoate decaprenyltransferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion integral component of mitochondrial inner membrane Biological process glycerol metabolic process isoprenoid biosynthetic process ubiquinone biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27235 71883 Ensembl ENSG00000173085 ENSMUSG00000029319 UniProt Q96H96 Q66JT7 RefSeq (mRNA) NM_015697 NM_001358921 NM_027978 RefSeq (protein) NP_056512 NP_001345850 NP_082254 Location (UCSC) Chr 4: 83.26 – 83.28 Mb Chr 5: 100.8 – 100.82 Mb PubMed search [3] [4]
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CoQ (ubiquinone) serves as a redox carrier in the mitochondrial respiratory chain and is a lipid-soluble antioxidant. COQ2, or parahydroxybenzoate-polyprenyltransferase (EC 2.5.1.39), catalyzes one of the final reactions in the biosynthesis of CoQ, the prenylation of parahydroxybenzoate with an all-trans polyprenyl group (Forsgren et al., 2004).[supplied by OMIM]^[6]